Hub-and-spoke Research Enclave
May 25, 2026 ยท View on GitHub
A Hub-and-Spoke Azure enclave for secure research.
Purpose
To accelerate the deployment of a hub-and-spoke architecture for building secure research enclaves in Azure.
Architecture

Features
- Optional use of customer-managed keys for encryption at rest (required for FedRAMP Moderate and similar compliance requirements).
- Optional peering to a central hub.
- Choice between Active Directory or Entra ID for device authentication and management. Optionally, use Intune for device management with Entra ID.
Compliance
The goal of the project is that the templates will deploy resources that are compliant with the following frameworks (according to the Azure Commercial built-in initiatives):
- HITRUST/HIPAA
- NIST 800-171 R2
- FedRAMP Moderate
Compliance with all the above frameworks is a work-in-progress.
Deployment
Deployment documentation is found in the Wiki.
Alternative research enclave accelerators
- Azure TRE: https://microsoft.github.io/AzureTRE/
- Standalone Azure Secure Enclave for Research: https://github.com/microsoft/Azure-Secure-Enclave-for-Research