react-msaview (JBrowseMSA)

An interactive multiple sequence alignment viewer.

Features

• Tree and alignment rendered together, tiled to stay fast on large inputs
• Parses FASTA, Stockholm, Clustal, A3M, and EMF alignments and Newick/EMF trees
• Protein domain overlays from InterProScan GFF (generate them with the CLI)
• Protein and nucleotide color schemes, including per-column dynamic schemes
• React component, UMD-in-HTML, and R htmlwidget entry points
• Shareable view state and SVG export

Documentation

Jump to what you need:

You want to…	Start here
Use the viewer — load data, explore, export an image	User guide · live app · docs site
Embed the React component in your own app	Usage & embedding guide · live code examples · model API reference
Use it from R (ape, Biostrings, ggtree, Shiny)	R package README
Annotate protein domains from an alignment	CLI README — batch InterProScan → GFF
Contribute / hack on the code	Development

Quick start (React)

npm install react-msaview @jbrowse/core @mui/material @emotion/react @emotion/styled react react-dom

import { MSAViewer } from 'react-msaview'

export default function App() {
  // backticks (template literal) so the \n become real newlines
  return (
    <MSAViewer
      msa={`>human\nMKAANSE\n>mouse\nMKA-NSE`}
      tree="(human:0.1,mouse:0.2);"
      colorScheme="clustal"
    />
  )
}

No model creation, width management, or theme provider needed. For the model-based API, UMD bundle, and full prop reference see USAGE.md, and browse runnable snippets in the live examples.

Quick start (R)

library(msaviewr)
msaview(msa = "alignment.fasta", tree = "tree.nwk", color_scheme = "clustal")

See the R package README for ape, Biostrings, ggtree, treeio, and Shiny usage.

Protein domains

Domain annotations (e.g. the GFF emitted by the CLI) overlay as labelled boxes on the alignment:

Packages

Package	Description
packages/lib	Main react-msaview React component
packages/website	Docs site (deployed at gmod.org/JBrowseMSA)
packages/app	Demo application (deployed at gmod.org/JBrowseMSA/demo)
packages/examples	Live usage examples (deployed at the Storybook link above)
packages/cli	Command-line tools (batch InterProScan)
packages/msa-parsers	MSA file format parsers
packages/r-msaview	R htmlwidget (ape/ggtree/Biostrings/treeio interop)
packages/svgcanvas	SVG canvas rendering (ESM fork of svgcanvas)

Development

git clone https://github.com/GMOD/react-msaview
cd react-msaview
pnpm install

Command	What it does
pnpm dev	Run the demo app with hot reload (edits in packages/lib/src/)
pnpm --filter examples dev	Run the live examples gallery
pnpm build	Build all packages
pnpm test	Run the test suite
pnpm figures	Regenerate the README figures (headless SVG, packages/lib/scripts)
pnpm screenshots	Regenerate the user-guide app screenshots (scripts/screenshots)
pnpm lint / format / typecheck	Lint, format with Prettier, typecheck all packages

Architecture notes live in CLAUDE.md; the core state model is packages/lib/src/model.ts (MobX-state-tree), and observer-wrapped components re-render when observed model properties change.

Deployment

• Docs site → gmod.org/JBrowseMSA, with the demo app at gmod.org/JBrowseMSA/demo. pnpm build:pages builds both into pages-dist/ (docs at the root, app under /demo); the Deploy docs site workflow publishes it to the gh-pages branch on every push to main. To deploy by hand: pnpm deploy:pages.
• Examples gallery → jbrowse.org/storybook/msa is deployed separately and must be run locally (it needs AWS credentials): pnpm deploy:storybook.

Releasing

Run scripts/release.js to create and push a new git tag. We use npm trusted publishing, so pushing a tag to GitHub launches the npm release automatically.

Related projects

• jbrowse-plugin-msaview — a JBrowse 2 plugin for viewing MSAs, supported by this repo
• ProteinBrowser — a full suite of protein analysis tools built on this viewer

Builds on abrowse and phylo-react.