OM_Hardware.md
June 21, 2026 · View on GitHub
Project | Description | Resources |
|---|---|---|
| - | Free and open-source automated 3-D microscope. Pearce lab. | Wijnen2016, Wiki |
| 3DSMLM | Build and operation of a custom 3D, multicolor, single-molecule localization microscope. Ries lab. | Power2024, GitHub.io |
| AttoBright | Single-molecule detection on a portable 3D-printed microscope. Gambin lab. | Brown2019, GitHub |
| Autocollimator | Autocollimator to align 4f systems. Gareme Johnaston and Brian Patton. | FocalPlane |
| Beamerscope | Using machine-learning to optimize phase contrast in a low-cost cellphone microscope. | Diederich2018, GitHub |
| Brick-MIC | Single-molecule detection and super-resolution imaging with a portable and adaptable 3D-printed microscopy platform. Cordes lab. | MoyaMunoz2024, MoyaMunoz2026, Zenodo |
| Bright-Eyes TTM | Open-Source Time-Tagging Module for Single-Photon Microscopy. | Rosetta2021, GitHub |
| cellSTORM | dSTORM using cellphone cameras and on-device neural network reconstruction. | Diederich2019, GitHub |
| cellSTORM II | Single-molecule localization microscopy using waveguide-based cellphone microscopy and 3D printing. | Diederich2020, GitHub |
| Crossbill | Open access single objective light-sheet microscopy platform | Kumar2021, Zenodo/GitHub |
| cryoscope | A super-resolution fluorescence cryomicroscope. Sharp lab. | Last2024, GitHub |
| DVD Laser Scanner Microscope | Recycling and upgrading parts to form high-resolution fluorescence microscopy. | Website |
| descSPIM | Affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques. Susaki lab. | Otomo2024, Github |
| DIY Camera Test Bench | Low-cost, Do-It-Yourself (DIY), test bench setup that closely follows the currently recognized standard on camera performance evaluation (EMVA 1288). | Website |
| DIY SDCM | Versatile, do-it-yourself, low-cost spinning disk confocal microscope | Halpern2021 |
| eduWOSM | The eduWOSM: an advanced optical microscope for education. | Carter2024, Website |
| easySTORM | easySTORM: a robust, lower-cost approach to localisation and TIRF microscopy. French lab. | Kwakwa2015 |
| eduSPIM | An educational light sheet microscope. Huisken lab. | Jahr2016 |
| EnderScope | A low-cost 3D printer-based scanning microscope for microplastic detection. Pickering lab. | Burke2024, GitHub |
| Entomoscope | An open-source photomicroscope for biodiversity discovery. Pylatiuk lab. | Wührl2024, OSFHOME |
| ESPressoscope | A small and powerful approach for in situ microscopy. Diederich lab. | Li2024, GitHub |
| fairSIM | Open-source structured illumination microscopy. Huser & Müller lab. | Markwirth2019, GitHub |
| Filters for microscopy | 3D printed DIY filters for oblique ilumination and dark field microscopy. | Github-Contrast, Github-DarkField |
| Fluorescent Imaging System | Low cost and open source multi-fluorescence imaging system for teaching and research in biology and bioengineering | Nunez2017 |
| FlyPi | A 3D-printable open-source platform for fluorescence microscopy, optogenetics, and accurate temperature control during behaviour of zebrafish, Drosophila, and Caenorhabditis elegans | Chagas2017 |
| Foldscope | Origami-based paper microscope. Prakash-lab. | Cybulski2014, Website |
| Hackteria Microscopy | Very cheap microscopy for teaching | Wiki |
| HIT SIM | Self-contained and modular structured illumination microscope. | Van_denEynde2021 |
| High-throughput cell biology | Open-source framework for automated high-throughput cell biology experiments. | Katunin2021, GitHub |
| Incubation box | Microscope incubation box for home built single molecule microscope. Holden lab. | GitHub |
| Incubot | A 3D printer-based microscope for long-term live cell imaging within a tissue culture incubator. Pickering lab. | Merces2021 |
| Incustream | An Open-Hardware Live-Cell Imaging System Based on Inverted Bright-Field Microscopy and Automated Mechanical Scanning for Real-Time and Long-Term Imaging of Microplates in Incubator | Gürkan2019 |
| Janelia Research Campus Tools and Innovations | Collection of helpful tools, data and resources that can be created in the lab. | Website |
| K2 TIRF | Open-source simultaneous triple-color TIRF microscope for live-cell and single-molecule imaging. Ganzinger Lab. | Niederauer2022, GitHub |
| Laser Engine | Blueprints for a low-cost laser engine for wide-field and localization microscopy. Ries lab. | Schröder2020, GitHub |
| LEGOLish | LEGO(R)-based Light sheet microscopy. | Website (offline) |
| LEMOLish | LEGO(R)-based Light sheet microscopy of cleared samples. | Website |
| LifeHack | An open-source, modular microscope for live & fixed cell single-molecule imaging. Holden lab. | GitHub |
| liteTIRF | Super-resolution microscopy for 20k Euros. Jungmann lab. | Auer2018, Weblink |
| LITOS | Versatile LED illumination tool for optogenetic stimulation. Pertz lab. | Höhner2022, GitHub |
| LSFM | Laser-free super-resolution microscopy (LFSM). High-density superresolution microscopy with an incoherent light source and a conventional epifluorescence microscope setup by Kirti Prakash. | Prakash2021 |
| Luduscope | Accessible Interactive Smartphone Microscopy for Life-Science Education. | Kim2016 |
| MatchboxScope | ESP32-based mini microscope for belo 10 Euros. | GitHub |
| mcSIM | Code for designing, analyzing, and carrying out multicolor structured illumination microscopy experiments. Additional tools for digital micromirror device SIM (DMD-SIM), including DMD simulation code, DMD pattern generation, SIM reconstruction and instrument control. (Python and Java) | Brown2021, GitHub |
| M4All | Modular, Monolithic, 3D printed High-end Microscopy with multicolour detection and Raspberry Pi camera-based readout. | GitHub |
| MEMS-SIM | SIM microscope using 3-axis MEMS mirrors for £9k. | Tinning2022, GitHub |
| MesoSPIM | Advanced large-scale light sheet system. | Voigt2019, Website |
| Microbrew | Small microscope to visualize yeast cell growth for beer brewing purposes | GitHub |
| Microscopi | Democratising “Microscopi”: a 3D printed automated XYZT fluorescence imaging system for teaching, outreach and fieldwork | Wincott2022, Components and Assembly |
| MicroscoPY | Lego and 3D printed Raspberry Pi-based microscope. | GitHub |
| microFPGA | MicroFPGA: an affordable field programmable gate array platform for microscope control. Ries lab. | Deschamps2022, GitHub.io, GitHub |
| miCube | Monolithic single-molecule localization microscope. Hohlbein lab. | Martens2019, GitHub.io |
| miEye | Monolithic single-molecule localization microscope based on the miCube adding autofocus and software control. Tutkus lab. | Alsamsam2022, GitHub, OSFhome |
| Miniscope | Circuit investigations with open-source miniaturized microscopes: Past, present and future | Aharoni2019, GitHub, Wiki |
| miniSPIM | Smartphone-based light-sheet microscope | Hedde2021 |
| µCube | A framework for 3D printable optomechanics. Haseloff lab 2018. | Delmans2018, GitHub |
| NanoJ-fluidics | Open-source fluid exchange in microscopy. Henriques lab. | Almada2019, GitHub |
| NicoLase | An open-source diode laser combiner, fiber launch, and sequencing controller for fluorescence microscopy. Gaus lab. | Nicovich2017, GitHub |
| Octopi | Open configurable high-throughput imaging platform for infectious disease diagnosis in the field. Prakash lab. | Li2019, GitHub |
| OLU | OLU: One- & Two-Photon Light-Sheet Microscope Design. Bormuth lab. | Hubert2023, GitHub |
| OpenFlexure Microscope | A 3D printed, laboratory-grade, open-source microscope, based on monolithic flexure stage. Bowman lab. | Collins2020, Website, GitLab |
| OpenFlexure Block Stage | A 3D printed 3-axis flexure translation stage for open-source fibre alignment (and microscopy). Bowman lab. | Meng2020, Website, GitLab |
| OpenFlexure Delta Stage | A 3D printed 3-axis flexure translation stage for open-source microscopy. Bowman lab. | McDermott2022, Website, GitLab |
| OpenFlexure Field Dissection Microscope | A microscope for looking at objects that are a few mm across, such as bees. | Website, GitLab |
| OpenFlexure Flat-Top Microscope | A laser-cut flat-top microscope for imaging larger items such as 96-well plates, flexure focussing mechanism. Bowman lab. | Website, GitLab |
| openFrame | Modular, low-cost, open-hardware microscopy platform that can be configured or adapted to most light microscopy techniques. | Lightley2023, GitHub |
| Open Ocular | Open-Source 3D printable eyepiece adapter for the cellphone. | Website |
| open OPT | Design and implementation of a custom built optical projection tomography system. | Wong2013 |
| openRAMAN | Low Cost, High Performances, 100% Open Source Raman Spectrometer | Website |
| OpenSPIM | An Open Access platform for applying and enhancing selective plane illumination microscopy. | Pitrone2013, Website/Wiki |
| openSpin | Various optical setups for large scale projection/tomography-based imaging. | Website |
| OPTiM | Optical projection tomography integrated microscope using open-source hardware and software. | Watson2017 |
| OptiJ | Optical projection tomography with Fiji. | Ramirez2019 |
| OPenT | Optical micro tomography. Martins lab. | Felix2016 |
| pDPC | Open-source implementation of polarisation-resolved single-shot differential phase contrast microscopy (pDPC) on a modular openFrame-based microscope. French lab. | Liu2025, Zenodo |
| pgFocus | pgFocus is an open source and open hardware, for noncommercial use, focus stabilization device developed by Karl Bellvé. | Bellve2014, Wiki (offline) |
| Picroscope | Development of a low-cost system for simultaneous longitudinal biological imaging. | Victoria2021, Github |
| PlanktonScope | Sea and plankton imaging for citizen science. Prakash lab. | Pollina2020, Website |
| Pi-based FPM | Low-cost, sub-micron resolution, wide-field computational microscopy using opensource hardware. Waller lab and Konda lab. | Aidukas2019 |
| PiFocus | Astigmatism-based active focus stabilisation with universal objective lens compatibility, extended operating range and nanometer precision. | Rahmani2024, GitHub, Zenodo |
| PUMA | Modular, option to add SLM, heads up display etc. | GitHub, Tadrous2021 |
| Raspi-based Fluorescence Microscope | Facile assembly of an affordable miniature multicolor fluorescence microscope made of 3D-printed parts enables detection of single cells. | Tristan-Landin2019 |
| RiesPieces | Repository of different microscope parts from the Ries lab, including a filter wheel, a flip mount, a linear stage, a magnetic sample holder, and solutions for illumination and focus locking. | GitHub |
| Red2PMic | Affordable open-source 2-photon microscope | GitHub |
| Sample preparation for light-sheet microscopy | Resources for preparing light-sheet samples in, e,g., FEP tubes or glass capillaries. | HuiskenLAB |
| ShinyaBlades | An OpenSource CoverSlips thickness detector for 3d printing | Github |
| Smartphone Fluorescence Spectroscopy | A smartphone spectrophotometry for readout of fluorescence-based biological assays. | Yu2014 |
| STORM | A blueprint for cost-efficient localization microscopy. Sauer lab. | Holm2014 |
| Strobe microfluidics stage | Workstation suitable for local digital fabrication for imaging fast processes, particularly for microfluidic droplet generation. Wenzel lab. | GitHub |
| smfBox | Microscpe for single-molecule FRET. | Ambrose2020, GitHub.io |
| Squid | Squid: Simplifying quantitative imaging platform development and deployment. Prakash lab. | Li2020, Website |
| Syringe pumps | Ender3 3D printer kit transformed into open, programmable syringe pump set. Saggiomo lab. | Baas2021, GitHub |
| TWINKLE | An open-source two-photon microscope for teaching and research. Thiberge lab. | Schottdorf2025, GitHub |
| Two-Photon | Open-source two-photon microscopy. Gordon lab. | Rosenberger2014 |
| UC2 [You.See.Too.] | UC2 is a general-purpose modular framework for making interactive (electro)-optical projects. Heintzmann lab. | Diederich2020, GitHub |
| UC2-Hi2 | High-throughput microscopy inside an incubator robot. | Ouyang2021, GitHub |
| UCsim2 | Super-resolution imaging using UC2 and DMDs. | Wang2021, GitHub |
| UC2-STORM-Fluorescence | An open-source, high resolution, automated fluorescence microscope based on the UC2. | Zehrer2024, GitHub |
| WOSM | The Warwick open source microscope for TIRF and educational fluorescence applications. | Website |
| Open Blink | The low-cost TIRF microscopy for single molecule super-resolution imaging with full µManager integration. Grußmayer Lab. | Huo2026, GitHub.io |