Scripts and data files for the epigenomic enrichment analysis of age-associated differentially methylated regions, and genes changing their expression with age. The results are published in Dozmorov, Mikhail G. “Polycomb Repressive Complex 2 Epigenomic Signature Defines Age-Associated Hypermethylation and Gene Expression Changes.” Epigenetics 10, no. 6 (2015): 484–95. https://doi.org/10.1080/15592294.2015.1040619.

data

Scripts to extract genomic coordinates of the age-associated genomic regions. The description of this folder contains the list of studies and the data available from them.

• Illumina - scripts to extract genomic coordinates of all CpG probes from Illumina Infinium 27K and Illumina Infinium 450K

• GenomeRunner - the results of the epigenomic enrichment analysis, and the scripts to process them

• R.Aging - R scripts for visualization of the results.

  • genes_promoters_extract.Rmd - extract promoters (+2000..-500bp arount TSS) of age-associated genes (data folder).